Call for New Clinical Trial Proposals

Call for proposals for innovative randomised clinical trials in allogeneic and autologous stem cell transplantation

The Clinical Trials Committee (CTC) of the British Society of Blood and Marrow Transplantation (BSBMT) in partnership with the IMPACT BMT Clinical Trials Network invites calls for outline proposals from prospective UK Chief Investigators for innovative randomised clinical trials in allogeneic and autologous stem cell transplantation.

IMPACT will particularly focus on randomised Phase II and Phase III trials addressing a variety of important issues in stem cell transplantation including transplant conditioning, graft-versus-host disease, post-transplant disease management and supportive care.  Proposals must be readily deliverable in a multi-centre format within the UK BMT network.  Proposals are expected for, but are not restricted to the most common indications for transplant including acute leukaemia, myeloma and lymphoma.  Studies investigating stem cell transplants in non-malignant disorders can also be considered.  Collaboration with industry is encouraged.

Outline proposals should be submitted to the BSBMT CTC Chair Dr Ram Malladi, BSBMT CTC Secretary Dr Victor Potter or the Medical Director of IMPACT Dr David Marks.  Selection of proposals for funding by IMPACT will follow a formal process of competitive external review with successful proposals to be automatically adopted into the NIHR trials portfolio.  It is expected that 3 trials per year over a 4 year period will be approved.  Applicants are encouraged to discuss trial ideas with us prior to submission of application.

The deadline for applications is Friday 6th September 2019 at 5pm. Please email completed application forms to

BSBMT IMPACT Study Proposal Application Form