IMPACT is the UK’s first ever clinical trials partnership dedicated to improving the outcomes of stem cell transplant patients.

A stem cell transplant is a potential cure for patients with a blood cancer or blood disorder, but there is an urgent need to improve patient outcomes. Of those who receive stem cells from an unrelated donor, fewer than half will reach the milestone of five-year survival.

This much-needed improvement in patient outcomes can only be achieved through research. Clinical trials are crucial in forming the evidence base for new approaches to treatment.

Improving patient outcomes

By providing the vital infrastructure that transplant centres need to work together, IMPACT will make it easier and quicker to deliver clinical trials that focus on improving stem cell transplant outcomes. As a result of this UK-wide partnership, IMPACT trials will reach a much larger patient population than would be possible at an individual transplant centre. There are dedicated IMPACT research nurses in ten centres, plus a further twelve affiliated centres which also participate in clinical trials.


IMPACT is a partnership of organisations committed to improving the outcomes of stem cell transplantation through cutting-edge research. It is jointly funded by Anthony Nolan, Leukaemia UK and NHS Blood and Transplant.


IMPACT is delivered in partnership with the British Society of Blood and Marrow Transplantation (BSBMT) and the Cancer Research UK Clinical Trials Unit (CRCTU) at the University of Birmingham.

Transplant Centres

There are IMPACT research nurses in eleven centres, plus a further eleven affiliated centres which also participate in clinical trials.

Transplant CentreLocationPrincipal Investigator
Addenbrooke's HospitalCambridgeDr Charles Crawley
Beatson West of Scotland Cancer CentreGlasgowDr Anne Parker
Churchill HospitalOxfordDr Andy Peniket
Freeman HospitalNewcastleProfessor Matthew Collin
King’s College HospitalLondonDr Victoria Potter
Manchester Royal InfirmaryManchesterDr Eleni Tholouli
Queen Elizabeth HospitalBirminghamProfessor Charlie Craddock
St James's University HospitalLeedsDr Jennifer Clay
University College London HospitalsLondonDr Kavita Raj
University Hospital of WalesCardiffDr Keith Wilson
University Hospitals BristolBristolDr Rachel Protheroe
Transplant CentreLocationPrincipal Investigator
The ChristieManchesterDr Adrian Bloor
Derriford HospitalPlymouthDr Hannah Hunter
Hammersmith HospitalLondonDr Eduardo Olavarria
Heart of EnglandBirminghamDr Emmanuel Nikolousis
Leicester Royal InfirmaryLeicesterDr Murray Martin
Nottingham City HospitalNottinghamDr Jenny Byrne
Royal Hallamshire HospitalSheffieldProfessor John Snowden
Clatterbridge Cancer CentreLiverpoolDr Yngvar Floisand
The Royal Marsden HospitalLondonDr Sandra Easdale
Southampton General HospitalSouthamptonDr Kim Orchard
St Bartholomew's HospitalLondonDr Jeff Davies